文献类型：期刊文献

英文题名：A Study on the Crystal Transformation Relationships of Valacyclovir Hydrochloride Polymorphs: Sesquihydrate, Form I, and Form II

作者：Wu, Yan-Fang[1];Zhang, Hao[1];Wang, Nai-Xing[2];Chen, Tian[2];Liu, Yan[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Zhejiang Charioteer Pharmaceut Co Ltd, Xianju 317321, Zhejiang, Peoples R China

年份：2021

卷号：56

期号：12

外文期刊名：CRYSTAL RESEARCH AND TECHNOLOGY

收录：;EI(收录号：20213910959066);WOS:【SCI-EXPANDED(收录号:WOS:000700949500001)】；

语种：英文

外文关键词：crystallization; dehydration; hydrate; phase transformation; polymorph; process analytical technology (PAT)

摘要：Valacyclovir hydrochloride is a kind of antiviral drug and has several crystal forms including sesquihydrate (SH), anhydrous Form I, and Form II. Here, the dehydration process of SH by heat drying is investigated by powder X-ray diffraction, differential scanning calorimetry, thermogravimetry analysis, vapor sorption analysis, and ReactRaman spectroscopy, and the dehydration and absorption of crystal water are revealed. The transformations of SH to Form I, Form II to Form I, and SH to Form II in aqueous ethanol suspension are monitored by ReactRaman spectroscopy, and the mechanisms of two different transition processes are defined through the analysis of ReactRaman spectra. The crystal transformation relationship of the mentioned forms is established.