文献类型：期刊文献

英文题名：Cobalt-Catalyzed Enantioselective Radical Carbamoylation of Ketimines

作者：Zhao, Wenyu;Chen, Yifeng[1,2]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai 200237, Peoples R China

年份：2026

外文期刊名：SYNLETT

收录：;Scopus(收录号：2-s2.0-105046466725);WOS:【SCI-EXPANDED(收录号:WOS:001845967000001)】；

基金：This work was supported by the Key Project of Science and Technology Innovation 2030 (No. 2023ZD0121001), National Natural Science Foundation of China (22371071, 22571081, 9235630), Science and Technology Commission of Shanghai Municipality (grant No.24DX1400200), the Program of Introducing Talents of Discipline to Universities (B16017), Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM404), Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025108) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：chiral amides; cobalt catalysis; carbamoyl chlorides; radical addition; asymmetric synthesis

摘要：Chiral amides are key motifs in pharmaceuticals and natural products, driving the need for efficient synthetic methods. Among them, those bearing tetrasubstituted stereocenters are particularly valuable yet synthetically challenging. Herein, we report a cobalt-catalyzed asymmetric carbamoyl addition to imines, providing straightforward access to structurally demanding alpha,alpha-disubstituted alpha-amino amides under mild conditions with excellent enantioselectivity. This modular strategy also enables a one-pot cascade to enantioenriched 2,5-diketopiperazines (DKPs), valuable scaffolds in medicinal chemistry. Mechanistic studies suggest that a stereoselective carbamoyl radical addition is the key step in chiral C-C bond formation.