文献类型：期刊文献

中文题名：Photodynamic Therapy of Oligoethylene GlycoI-Dendronized Reduction-Sensitive Porphyrins

英文题名：Photodynamic Therapy of Oligoethylene GlycoI-Dendronized Reduction-Sensitive Porphyrins

作者：Mingjie Ju[1];Jundi Pang[2];Ligong Xu[1]

机构：[1]School of Sports Science and Engineering, East China University of Science and Technology, Shanghai 200237, China;[2]Kunming Medical University, Kunming, Yunnan 650500, China

年份：2017

卷号：35

期号：9

起止页码：1445

中文期刊名：Chinese Journal of Chemistry

外文期刊名：中国化学（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2017_2018】；

语种：英文

中文关键词：graphene oxide;photodynamic therapy;porphyrindisulfide

外文关键词：graphene oxide, photodynamic therapy, porphyrindisulfide

摘要：Graphene oxide （GO） and its functionalized derivatives have attracted increasing attention in medical treatment. Herein, a reduction sensitive PEI-GO-SS-TPP was synthesized for photodynamic therapy. More than 80% porphyrin release was observed in the presence of 10 mmol·L^-1 DTT in one day. The confocal laser scanning microscopy confirmed that the cell uptake efficiency of PEI-GO-SS-TPP was remarkably enhanced as compared to free porphyrin which was significantly dependent on incubation time. For photodynamic therapy, GSH-OEt could effectively increase the photodynamic therapy efficiency of PEI-GO-SS-TPE Compared with free porphyrin, the toxicity from PEI-GO-SS-TPP is much higher with a low IC50 （2.1 μg/mL） value. All results indicate that the PEI-GO-SS-TPP PSs are promising for photodynamic therapy.
Graphene oxide （GO） and its functionalized derivatives have attracted increasing attention in medical treatment. Herein, a reduction sensitive PEI-GO-SS-TPP was synthesized for photodynamic therapy. More than 80% porphyrin release was observed in the presence of 10 mmol·L^-1 DTT in one day. The confocal laser scanning microscopy confirmed that the cell uptake efficiency of PEI-GO-SS-TPP was remarkably enhanced as compared to free porphyrin which was significantly dependent on incubation time. For photodynamic therapy, GSH-OEt could effectively increase the photodynamic therapy efficiency of PEI-GO-SS-TPE Compared with free porphyrin, the toxicity from PEI-GO-SS-TPP is much higher with a low IC50 （2.1 μg/mL） value. All results indicate that the PEI-GO-SS-TPP PSs are promising for photodynamic therapy.