文献类型：期刊文献

英文题名：Synthesis of Indolizines via Reaction of 2-Substitued Azaarenes with Enals by an Amine-NHC Relay Catalysis

作者：Li, Hongxian[1,2];Li, Xiangmin[1,2];Yu, Yang[1,2];Li, Jianjun[1,2];Liu, Yuan[1,2];Li, Hao[1,2];Wang, Wei[1,2,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioengn Reactor, Shanghai Key Lab New Drug Design, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[3]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2017

卷号：19

期号：8

起止页码：2010

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000400123600019)，CCR-EXPANDED(收录号:WOS:000400123600019)】；

基金：Financial support of this research from the program for the National Science Foundation of China (21372073, 21572054, and 21572055), the Fundamental Research Funds for the Central Universities, and the China 111 Project is gratefully acknowledged.

语种：英文

摘要：A metal-free catalytic strategy for the facile synthesis of biologically relevant molecular architectures indolizines and imidazopyridines has been developed. The process is promoted by amine and N-heterocyclic carbene (NHC) relay catalysis via Michael addition-[3 + 2] fusion of simple azaarenes and alpha,beta-unsaturated aldehydes. The preparative power is demonstrated in the synthesis of anxiolytic drug saripidem via two simple one-pot operations with overall 45% yield.