文献类型：期刊文献

英文题名：Combined Anserine/Carnosine Exerts Anti-Hyperuricemic, Nephroprotective, and Gut Microbiota-Modulating Effects in Hyperuricemia Mice

作者：Huang, Jingjing[1,2];Dang, Zheng[1];Zhang, Yuzhi[1];Lin, Haisheng[2];Du, Lei[1,2];Zhang, Jie[1];Zhao, Li[1];Chang, William T. H.[3];Kong, Xiang-Ru[4];Tseng, Wei-Ting[4];Xie, Jingli[1,5]

机构：[1]East China Univ Sci & Technol, Sch Biotechnol, Dept Food Sci & Engn, State Key Lab Bioreactor Engn, Shanghai, Peoples R China;[2]Guangdong Ocean Univ, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang, Peoples R China;[3]Lytone Enterprise Inc, Res & Dev Dept, Taipei, Taiwan;[4]Shanghai Lytone Biochem LTD, Res & Dev Dept, Shanghai, Peoples R China;[5]Shanghai Collaborat Innovat Ctr Biomfg, Shanghai, Peoples R China

年份：2026

卷号：5

期号：2

起止页码：194

外文期刊名：FOOD BIOENGINEERING

收录：EI(收录号：20262420885604);WOS:【ESCI(收录号:WOS:001789163000001)】；

基金：This work was supported by the Shanghai Agricultural Science and Technology Innovation Project (202402080012F00030), Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety (GDPKLAPPS2001).

语种：英文

外文关键词：carnosine and anserine; correlation analysis; gut microbiota; hyperuricemia; kidney protection

摘要：The anti-hyperuricemic, nephroprotective, and gut microbiota modulation effects of mixed carnosine and anserine (MAC) with the fixed ratio of 10:1 were evaluated in the hyperuricemic model mouse. The low- and high-dose (1.6 and 8.3 mg/kg BW) of MAC could significantly reduce serum uric acid (UA) level by 58% and 56%, close to the normal level, respectively. The MAC significantly inhibited xanthine oxidase activity in both hepatic tissue and serum. Furthermore, MAC treatment ameliorated the renal injury indicated by the normalized serum creatinine and urea nitrogen levels, recovered histopathological characteristics, mitigated oxidative stress, and suppressed proinflammatory cytokines. Notably, MAC could accelerate UA excretion by markedly downregulating the expression of the URAT1 and GLUT9, while upregulating the transporter OAT1. Gut microbiota analysis demonstrated that MAC restored intestinal microbial diversity in hyperuricemic mice and reduced the abundance of genera linked to hyperuricemia and inflammation. All the results proved MAC as potential UA-lowering treatment.