文献类型：期刊文献

英文题名：Synthesis of oxa-bridged carbocycles via rhodium/Lewis acid catalyzed [3+3] and [4+3] cycloadditions of carbonyl ylides with donor-acceptor strained carbocycles

作者：Li, Jiale[1];Wang, Lingfei[1];Liu, Pei-Nian[1,2];Li, Xingguang[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]China Pharmaceut Univ, Sch Pharm, State Key Lab Nat Med, Nanjing 210009, Peoples R China

年份：2025

卷号：12

期号：2

起止页码：491

外文期刊名：ORGANIC CHEMISTRY FRONTIERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001352597100001)，CCR-EXPANDED(收录号:WOS:001352597100001)】；

基金：We are grateful to the National Natural Science Foundation of China (No. 22201073, 21925201, and 22161160319) and the Fundamental Research Funds for the Central Universities. We thank the Research Center of Analysis and Test of East China University of Science and Technology for help in characterization.

语种：英文

摘要：A method for cooperative rhodium/Lewis acid-catalyzed [3 + 3] and [4 + 3] cycloadditions of carbonyl ylides with donor-acceptor (D-A) strained carbocycles is described. It affords access to a wide range of structurally diverse oxa-bridged carbocycles with high efficiency and stereoselectivity. This method operates under mild conditions, exhibits good step and atom economy, and can be extended to [3 + 2] cycloadditions with D-A 1,2-dipoles, enabling the construction of oxa-bridged spirocycles.