文献类型：期刊文献

中文题名：喷雾干燥法制备载药微球时的形貌与粒度控制

英文题名：MORPHOLOGY AND SIZE CONTROL OF DRUG-LOADED MICROSPHERE BY SPRAY DRYING METHOD

作者：储茂泉[1];刘国杰[2]

机构：[1]同济大学生命科学技术学院,上海200092;[2]华东理工大学化学与制药学院,上海200237

年份：2004

卷号：55

期号：11

起止页码：1903

中文期刊名：化工学报

外文期刊名：CIESC Journal

收录：CSTPCD;;EI(收录号：2005058821443);Scopus;北大核心:【北大核心2000】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：喷雾干燥;载药微球;形貌;粒度

外文关键词：Drug therapy;Drying;Morphology;Particle size analysis

摘要：Drug-loaded microspheres are usually used as a biophysically targeted delivery system.The morphology and size distribution of the microspheres are key effects on the efficiency in therapy.The microspheres could be prepared by the spray drying method, and the characterization could be controlled by varying the drying conditions.The whole preparation process is highly efficient, and suitable for commercialization.In this work,a case for preparation of the microspheres of tanshinone (TAN) solid dispersions was studied, and the mechanisms of morphology and size control of microspheres during the spray drying process were investigated.The effects of inlet temperature,concentration and components of precursors, and feed rate on the morphology and size distribution of products were studied.The results showed that the morphology of the dry products depended on the inlet temperature, the components of precursor and feed rate.Among them,temperature was the most important factor.The size of microspheres was mainly controlled by the concentration of the precursor.This work might be a reference for morphology and size control of targeted drug delivery microspheres by the spray drying method.
Drug-loaded microspheres are usually used as a biophysically targeted delivery system. The morphology and size distribution of the microspheres are key effects on the efficiency in therapy. The microspheres could be prepared by the spray drying method, and the characterization could be controlled by varying the drying conditions. The whole preparation process is highly efficient, and suitable for commercialization. A case for preparation of the microspheres of tanshinone (TAN) solid dispersions was studied, and the mechanisms of morphology and size control of microspheres during the spray drying process were investigated. The effects of inlet temperature, concentration and components of precursors, and feed rate on the morphology and size distribution of products were studied. The results show that the morphology of the dry products depends on the inlet temperature, the components of precursor and feed rate. Among them, temperature was the most important factor. The size of microspheres was mainly controlled by the concentration of the precursor. This work might be a reference for morphology and size control of targeted drug delivery microspheres by the spray drying method.