文献类型：期刊文献

英文题名：Palladium(0)-Catalyzed Iminohalogenation of Alkenes: Synthesis of 2-Halomethyl Dihydropyrroles and Mechanistic Insights into the Alkyl Halide Bond Formation

作者：Chen, Chen[1];Hou, Longlei[1];Cheng, Mian[1];Su, Jianhua[1];Tong, Xiaofeng[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2015

卷号：54

期号：10

起止页码：3092

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20150500459202);WOS:【SCI-EXPANDED(收录号:WOS:000350302300040)，CCR-EXPANDED(收录号:WOS:000350302300040)】；

基金：This work is supported by NSFC (No. 21472042), the Fundamental Research Funds for the Central Universities, Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China (131011), and NCET (No. 12-0851).

语种：英文

外文关键词：elimination; halogenation; heterocycles; palladium; synthetic methods

摘要：Although the advances on carbon halide reductive elimination have been made, the alkyl bromide and chloride analogues remain a challenge. Here, a palladium(0)-catalyzed iminohalogenation of ,-unsaturated oxime esters is described, and the use of electron-poor phosphine ligands proved to be crucial to promoting alkyl bromide and chloride reductive elimination. Furthermore, S(N)2-type alkyl bromide and chloride reductive elimination has also been established.