文献类型：期刊文献

中文题名：葛根素复合骨架缓释片的处方及制备工艺

英文题名：Preparation and Influencing Factors of Sustained-release Puerarin Tablet

作者：景秋芳[1];任福正[1];沈永嘉[1];胡良才[2]

机构：[1]华东理工大学化学与制药学院,上海200237;[2]沈阳药科大学,沈阳110016

年份：2003

卷号：29

期号：2

起止页码：173

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;EI(收录号：2003257514410);Scopus;北大核心:【北大核心2000】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：葛根素;海藻酸钠;甲壳胺;复合骨架缓释片;制备工艺;处方设计;释放度;心血管系统药物

外文关键词：puerarin; alginate sodium; chitosan; sustained-release tablet

摘要：以甲壳胺(CS)和海藻酸钠(AL)为辅料制备复合骨架葛根素缓释片,考察了制备工艺和辅料性质对骨架片释放度的影响,并通过正交试验对缓释片的处方进行优化。结果表明:直接压片释放过缓;润湿剂对干颗粒的理化性质有影响。CS的用量、脱乙酰度和AL的粘度对释放度影响显著;CS密度及AL的粒度对释放度影响一般。
The preparation and influencing factors of the polysaccharides matrix sustainedrelease tablets of puerarin and the process of the tablet were studied. The optimal formulation was found using orthogonal experiment design. The decreasing rate was caused by direct compression. Some kinds of wetting agents influenced the properties of the dry granules and the release rate was sensitive to the hardness of PUE tablet. The content and degree of deacetylation of chitosan (CS) and the viscosity of alginate sodium (AL) had significant effects; whereas the density of CS and the granularity of AL had some influence on the release rate.