文献类型：专利

英文题名：New pteridinone derivative useful in pharmaceutical composition for treating blood diseases chosen from myeloproliferative disorder, cancer, immune disease and skin disease chosen from psoriasis and atopic dermatitis

作者：LI H;XU Y;CHEN Z;SUN D;LV J;ZHAO Z;SONG W;ZHOU W;YANG Y

机构：[1]UNIV EAST CHINA SCI & TECHNOLOGY

申请号：WO2017148440-A1

申请日：2017-03-03

公开日：2017-09-08

语种：英文

收录：DERWENT

摘要：NOVELTY - A pteridinone derivative (I), is new. USE - Pteridinone derivative is used in pharmaceutical composition for treating FLT3-mediated disease chosen from blood diseases which is chosen from myeloproliferative disorder, cancer, immune disease and skin disease chosen from psoriasis and atopic dermatitis. The cancer is chosen from acute myeloid leukemia, mixed lineage leukemia, T-cell acute leukemia, B cell acute leukemia, chronic myelomonocytic leukaemia, chronic lymphocytic leukemia, chronic myeloid leukemia and chronic neutrophilic leukemia. The immune disease is chosen from arthritis, lupus, inflammatory bowel disease, rheumatoid arthritis, psoriatic arthritis, osteoarthritis, adult-onset still's disease, adolescent arthritis, diabetes mellitus, myasthenia gravis, Hashimoto's thyroiditis, Graves disease, rheumatoid arthritis syndrome, multiple sclerosis, infectious neuritis, acute transmissible encephalomyelitis, Addison's disease, aplastic anemia, autoimmune hepatitis, optic neuritis, psoriasis, graft versus host disease, transplantation, blood transfusion allergic reaction, type I hypersensitivity, allergic conjunctivitis, and allergic rhinitis. DETAILED DESCRIPTION - A pteridinone derivative of formula (I) or its salt, is new. X=N or CH; Y'=O, S or Se; A=substituted benzyl or nitrogen-containing 5-membered or 6-membered ring; R1=H, halo, 1-8C alkyl, 3-6C cycloalkyl, fluorinated 1-8C alkyl or optionally substituted phenyl; R2=H, halo, amino, -NR'R" or 1-6C alkyl, 1-6C alkoxy, alkoxycarbonyl, N-alkylpiperazin-1-yl, morpholin-4-yl, piperidinyl, pyrrol-1-yl, pyrrolidin-1-yl, aryl or arylmethyl, piperidyloxy or N,N',N'-trialkylenediamino (all optionally substituted); R',R"=H, 1-6C alkyl or alkenyl; n=0-4; R3=H, halo, hydroxy, amino, -NR13R14, 1-2C acylamino, 1-3C sulfonylamino, CN, carbamoyl, carboxy, 1-6C alkoxycarbonyl, 1-6C alkyl, phenyl, piperazinyl, morpholin-4-yl, pyrrol-1-yl or pyrrolidin-1-yl (all optionally substituted); R13,R14=R';and m=0-4. When n and m are 1 and R2 is 1-6C alkoxy, R3 is not amino.