文献类型：期刊文献

英文题名：Theranostic Fluorescent Probes

作者：Sharma, Amit[1];Verwilst, Peter[13];Li, Mingle[5];Ma, Dandan[5,14];Singh, Nem[2];Yoo, Jiyoung[2];Kim, Yujin[2];Yang, Ying[4];Zhu, Jing-Hui[5,14];Huang, Haiqiao[5,14];Hu, Xi-Le[7];He, Xiao-Peng[7,8,9];Zeng, Lintao[4];James, Tony D.[10,11];Peng, Xiaojun[5,6];Sessler, Jonathan L.[12];Kim, Jong Seung[2,3]

机构：[1]Amity Univ Punjab, Amity Sch Chem Sci, Mohali 140306, India;[2]Korea Univ, Dept Chem, Seoul 02841, South Korea;[3]TheranoChem Inc, Seoul 02841, South Korea;[4]Guangxi Univ, Sch Light Ind & Food Engn, Nanning 530004, Guangxi, Peoples R China;[5]Shenzhen Univ, Coll Mat Sci & Engn, Shenzhen 518060, Peoples R China;[6]Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China;[7]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[8]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Joint Int Res Lab Precis Chem & Mol Engn, Shanghai 200237, Peoples R China;[9]Eastern Hepatobiliary Surg Hosp, Natl Ctr Liver Canc, Int Cooperat Lab Signal Transduct, Shanghai 200438, Peoples R China;[10]Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China;[11]Univ Bath, Dept Chem, Bath BA2 7AY, England;[12]Univ Texas Austin, Dept Chem, Austin, TX 78712 USA;[13]Katholieke Univ Leuven, Rega Inst Med Res, Med Chem, B-3000 Leuven, Belgium;[14]Shenzhen Univ, Coll Phys & Optoelect Engn, Shenzhen 518060, Peoples R China

年份：2024

卷号：124

期号：5

起止页码：2699

外文期刊名：CHEMICAL REVIEWS

收录：;EI(收录号：20241015678240);WOS:【SCI-EXPANDED(收录号:WOS:001178781300001)】；

基金：The authors thank the financial support received from the National Research Foundation of Korea (CRI project no. 2018R1A3B1052702, J.S.K,), NSFC (grant no. 21978222, L.Z.). X.P. thanks the National Natural Science Foundation of China (No. 22090011), Fundamental Research Funds for the Central Universities (No. DUT22LAB608), and Shenzhen University 2035 Program for Excellent Research (No. 00000225). M.L. thanks the support of the National Natural Science Foundation of China (No. 22308220) and Shenzhen University Third-Phase Project of Constructing High-Level University (No. 000001032104). X.-P.H. thanks the Natural National Science Foundation of China (Nos. 92253306 and 82130099), the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03), the Fundamental Research Funds for the Central Universities (222201717003), the Programme of Introducing Talents of Discipline to Universities (B16017), and the Open Funding Project of the State Key Laboratory of Bioreactor Engineering. T.D.J. thanks the University of Bath and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University (2020ZD01) for support. A.S. thanks Department of Biotechnology, New Delhi, India, for a prestigious DBT-Ramalingaswami fellowship (BT/RLF/Re-entry/59/2018) and Science & Engineering Research Board, New Delhi (CRG/2021/002476).

语种：英文

外文关键词：Clinical research - Controlled drug delivery - Fluorescence spectroscopy - Neurodegenerative diseases - Probes - Targeted drug delivery

摘要：The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal control, in the context of drug delivery makes theranostic fluorescent probes an attractive and intensely investigated research topic. This interest is reflected in the steep rise in publications on the topic that have appeared over the past decade. Theranostic fluorescent probes, in their various incarnations, generally comprise a fluorophore linked to a masked drug, in which the drug is released as the result of certain stimuli, with both intrinsic and extrinsic stimuli being reported. This release is then signaled by the emergence of a fluorescent signal. Importantly, the use of appropriate fluorophores has enabled not only this emerging fluorescence as a spatiotemporal marker for drug delivery but also has provided modalities useful in photodynamic, photothermal, and sonodynamic therapeutic applications. In this review we highlight recent work on theranostic fluorescent probes with a particular focus on probes that are activated in tumor microenvironments. We also summarize efforts to develop probes for other applications, such as neurodegenerative diseases and antibacterials. This review celebrates the diversity of designs reported to date, from discrete small-molecule systems to nanomaterials. Our aim is to provide insights into the potential clinical impact of this still-emerging research direction.