文献类型：期刊文献

英文题名：Typing system based on ligase detection reaction for AGT M 235T and ACE ID gene polymorphism

作者：Zhang, Shi-Yang; Xiao, Zhen-Xian; Zhao, Jian-Long; Xiao, Jun-Hua; Cao, Hui-Min

机构：[1] State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China; [2] Institute of Biological Science and Technology, Donghua University, Shanghai 200051, China; [3] Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Science, Shanghai 200050, China

年份：2006

卷号：32

期号：9

起止页码：1050

外文期刊名：Huadong Ligong Daxue Xuebao /Journal of East China University of Science and Technology

收录：EI(收录号：20064610240512)

语种：英文

摘要：Gene polymorphism includes lots of genetic information. Typing technology is the main method to evaluate gene polymorphism. The parallel typing system based on ligase detection reaction is established for gene polymorphism. Ligase detection reaction and microarray assay are combined, which generating gene typing with high. The results by this method are the same as those by sequencing for typing AGT M235T and ACE I/D. The gene polymorphism of 168 Chinese people were determined. The significant (X2 = 6.191, P less than or equal 0.05) difference distribution of AGT M235T gene polymorphism was found between hypertension cases and healthy controls, but ACE I/D gene polymorphism is no significant difference among them (X2 = 5.241, P > 0.05).