文献类型：期刊文献

英文题名：Novel Melphalan and Chlorambucil Derivatives of 2,2,6,6-Tetramethyl-1-piperidinyloxy Radicals: Synthesis, Characterization, and Biological Evaluation in Vitro

作者：Zhao, Hongli[1,2,3];Meng, Xianjiang[1,2];Yuan, Huihui[1,2,3];Lan, Minbo[1,2,4]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Res Ctr Anal & Test, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Inst Appl Chem, Shanghai 200237, Peoples R China;[4]E China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2010

卷号：58

期号：3

起止页码：332

外文期刊名：CHEMICAL & PHARMACEUTICAL BULLETIN

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000275047200009)】；

语种：英文

外文关键词：melphalan; chlorambucil; 2,2,6,6-tetramethyl-1-piperdinyloxy radical; cytotoxic activity

摘要：A series of spin-labeled melphalan and chlorambucil derivatives, coupling the alkylating agents with 2,2,6,6-tetra tetramethyl-1-piperidinyloxy (TEMPO) radicals, were synthesized, characterized, and their biological properties in vitro were evaluated. These compounds showed much higher cytotoxic activity against human leukemia cell line K562 in vitro than their parent compounds.