文献类型：期刊文献

英文题名：Effects of black highland barley starch on regulating sustained glucose release and fluctuations in individuals with type 2 diabetes

作者：Deng, Shuxin[1];Ji, Xiaoguo[1,2];Wang, Jiaming[3];Fan, Liqiang[1,2];Jin, Jiayang[1,2];Li, Juan[3];Zhao, Liming[1,3,4]

机构：[1]East China Univ Sci & Technol, Sch Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Shanghai 200237, Peoples R China;[3]Shanghai Changzheng Hosp, Shanghai 200003, Peoples R China;[4]Shanghai Collaborat Innovat Ctr Biomfg Technol, Shanghai 200237, Peoples R China

年份：2026

卷号：15

期号：3

外文期刊名：FOOD SCIENCE AND HUMAN WELLNESS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001748644300001)】；

基金：This work was supported by the Shanghai Sailing Program (23YF1409800), Natural Science Foundation of Shanghai (23ZR1415400) and Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission).

语种：英文

外文关键词：Black highland barley; Starch structure; Type 2 diabetes; Glucose regulation; Gut metabolites

摘要：Consuming low-glycemic index foods, such as black highland barley (BHB), is essential for regulating post-meal glucose levels in individuals with type 2 diabetes mellitus (T2DM). This study examined how the starch structure of BHB affected glucose fluctuations. The incorporation of BHB enlarged starch granule size and modified the crystalline structure to an A + V type with a relative crystallinity of 31.14%. This alteration facilitated a more organized release of glucose. Population-based trials lasting 6 weeks had demonstrated that that BHB could reduce glucose variation, ghrelin levels, and insulin resistance in T2DM. Additionally, it increased the populations of beneficial gut bacteria such as Akkermansia, Bifidobacterium, and Lactobacillus, while also raising levels of gastric inhibitory peptides, phenolics, and specific gut metabolites. The specific digestion protocol and mathematical model of BHB disclosed its slow gastric emptying and glucose release rates, which were crucial for maintaining stable glucose levels in individuals with T2DM. Understanding the starch structure of BHB provided an effective dietary intervention for managing T2DM-related glucose fluctuations.