文献类型：期刊文献

英文题名：P-Chiral Monophosphorus Ligands for Asymmetric Copper-Catalyzed Allylic Alkylation

作者：Xiong, Wenrui[1];Xu, Guangqing[2];Yu, Xinhong[1];Tang, Wenjun[1,2]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, 130 Meilong Rd, Shanghai 200037, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

年份：2019

卷号：38

期号：20

起止页码：4003

外文期刊名：ORGANOMETALLICS

收录：;EI(收录号：20192507083791);WOS:【SCI-EXPANDED(收录号:WOS:000500027700017)】；

基金：We are grateful to the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB20000000), CAS (QYZDY-SSW-SLH029), NSFC-(21725205, 21432007, 21572246, and 21702223), and the K. C. Wong Education Foundation.

语种：英文

外文关键词：Alkylation - Allylation - Catalysis - Copper

摘要：Asymmetric copper-catalyzed allylic alkylation between allylic bromides and alkyl Grignard reagents using a P-chiral monophosphorus ligand is described. A range of terminal olefins bearing tertiary or quaternary carbon centers were formed in good branched/linear selectivities and excellent enantioselectivities at copper loadings as low as 0.5 mol %.