文献类型：期刊文献

英文题名：A micro/nano-biomimetic coating on titanium orchestrates osteo/angio-genesis and osteoimmunomodulation for advanced osseointegration

作者：Bai, Long[1,2,3,4,6,7];Chen, Peiru[5];Zhao, Ya[2];Hang, Ruiyue[2];Yao, Xiaohong[2];Tang, Bin[2];Liu, Changsheng[1,4,7];Xiao, Yin[3,6];Hang, Ruiqiang[2]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]Taiyuan Univ Technol, Coll Mat Sci & Engn, Inst New Carbon Mat, Lab Biomat Surfaces & Interfaces, Taiyuan, Peoples R China;[3]Queensland Univ Technol, Sch Mech Med & Proc Engn, Brisbane, Qld, Australia;[4]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China;[5]Natl Ctr Prot Sci Beijing, Beijing Proteome Res Ctr, Inst Life, State Key Lab Prote, Beijing 102206, Peoples R China;[6]Queensland Univ Technol, Australia China Ctr Tissue Engn & Regenerat Med, Brisbane, Qld, Australia;[7]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai 200237, Peoples R China

年份：2021

卷号：278

外文期刊名：BIOMATERIALS

收录：;EI(收录号：20214111001215);WOS:【SCI-EXPANDED(收录号:WOS:000710808200001)】；

基金：This work was jointly supported by the Funds for Shanxi "1331 Project" Key Innovative Research Team (PY201809) , Program for the Innovative Talents of Higher Education Institutions of Shanxi (PTIT) , China; Natural Science Foundation of Shanxi Province (201801D121093) , China; National Natural Science Foundation of China (81901898) , China; and China Postdoctoral Science Foundation (2019M661404, 2020T130192) , China. The authors would appreciate the financial support from the China Scholarship Council (CSC, 201606930017) , China.

语种：英文

外文关键词：Titanium; Biomimetic; Osteo-; angio-genesis; Osteoimmunomodulation; Osseointegration

摘要：Osseointegration is a sophisticated bone and implant healing process comprising of initial hematoma formation, immediate osteoimmunomodulation, angiogenesis, and osteogenesis. To fulfill rapid and satisfying osseointegration, this study developed a biomimetic implant coating that could confer the intraosseous implants a systematical regulation of the participatory processes. Herein, we shaped dissimilar nano-scale (NS) to form highly biomimetic structures of natural extracellular matrix (ECM) of the host bone and bone healing hematoma with micro/nano-scale (MNS) titania fiber-like network on the surface of titanium (Ti) implants. In vitro experiments revealed that the MNS not only facilitated osteogenic and angiogenic differentiation of bone marrow stromal cells (BMSCs) and endothelial cells, respectively, but also suppressed M1 macrophages (M phi s), whereas, stimulated pro-healing M2 phenotype. Notably, BMSCs on MNS surfaces enabled a significant immunomodulatory effect on M phi s resulting in the downregulation of inflammation-related cell signaling pathways. The favorable osteoimmune microenvironment manipulated by MNS further facilitated osteo-/angio-genesis via the crosstalk of multi-signaling pathways. In vivo evaluation mirrored the aforementioned results, and depicted that MNS induced ameliorative osseointegration when compared with the NS as well as the pristine Ti implant. The study demonstrated the modulatory effect of the multifaceted biomimetic structure on spatiotemporal regulation of the participatory processes during osseointegration.