文献类型：期刊文献

英文题名：Investigating the Photoactivity of Low-Valent Zirconium Catalyst in Ether Activation

作者：Zhao, Jie[1,2]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Joint Int Res Lab Precis Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2025

卷号：36

期号：07

起止页码：771

外文期刊名：SYNLETT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001374744600001)】；

基金：J.Z. thanks Prof. F. Dean Toste from UC Berkeley for helpful discussions.

语种：英文

外文关键词：zirconium; photoinduced; C-O bonds; cross-electrophile coupling; ether

摘要：The cross-coupling of two distinct C(sp(3))-O bonds provides a highly valuable pathway for the construction of C(sp(3))-C(sp(3)) bonds, but it remains underdeveloped. Recently, we reported an innovative photoinduced Zr-catalyzed carbomagnesiation for the reductive coupling of ethers with high cross-selectivity. Mechanistic investigation reveals that photoexcitation of low-valent zirconocene facilitates the activation of C(sp(3))-O bonds of benzylic ethers. This leads to the formation of functionalized benzylic Grignard reagents for downstream coupling with aliphatic ethers through an S(N)2-like pathway.