文献类型：期刊文献

英文题名：Fe3+-induced bioinspired chitosan hydrogels for the sustained and controlled release of doxorubicin

作者：Zhang, Jinmao[1];Tao, Xinyi[1];Liu, Jianwen[2];Wei, Dongzhi[1];Ren, Yuhong[1]

机构：[1]E China Univ Sci & Technol, New World Inst Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2016

卷号：6

期号：53

起止页码：47940

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20162302453289);WOS:【SCI-EXPANDED(收录号:WOS:000377253400088)】；

基金：This work was funded by the National Special Fund for the State Key Laboratory of Bioreactor Engineering (2060204) and the National major science and technology projects of China (No. 2012ZX09304009).

语种：英文

外文关键词：Addition reactions - Hydrogels - Targeted drug delivery - Amino acids - Controlled drug delivery - Gelation

摘要：In this study, a novel Fe3+-induced bioinspired chitosan hydrogel was developed to easily deliver the anticancer drug, doxorubicin (DOX). Catechol-chitosan conjugates (CCS) and an N-acetyl cysteine-chitosan conjugate (NACCS) were synthesized and used to prepare the hydrogels. The addition of NACCS accelerated the gelation rate and improved the mechanical strength of the hydrogels, due to the Michael addition reaction between NACCS and the oxidation product of CCS. This study demonstrated that the Fe3+-induced CCS-NACCS hydrogel was a dual covalent-coordination crosslinking system under acidic conditions. Release curves for DOX were evaluated at different pH values, and the release kinetics and mechanism were also investigated. The CCS-NACCS hydrogel showed no obvious toxicity and the DOX released from the hydrogel could effectively inhibit the proliferation of several kinds of tumor cells.