文献类型：期刊文献

英文题名：Facile synthesis of N-phenoxycarbonyl amino acids by a two-phase reaction for direct polymerization

作者：Zhang, Donghui[1,2]; Liu, Shiqi[1,3]; Cai, Zhihao[1,3]; Luo, Weizhe[1,3]; Liu, Guojian[1,3]; Liu, Runhui[1,3]

机构：[1] State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China; [2] School of Biotechnology, East China University of Science and Technology, Shanghai, 200237, China; [3] Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China

年份：2023

卷号：15

期号：2

起止页码：97

外文期刊名：Polymer Chemistry

收录：EI(收录号：20235115233217)

语种：英文

外文关键词：Column chromatography - Monomers - Polymerization

摘要：Polypeptides are extensively used in the fields of biomedicine and biomaterials. The use of N-phenoxycarbonyl amino acids (NPCs) as monomers for polypeptide synthesis is an advanced method that offers the unique advantage of excellent monomer stability. However, the purification of NPC monomers previously required laborious column chromatography or recrystallization techniques, which might have restricted the widespread application of NPC polymerization. In this work, a straightforward and efficient method for synthesizing NPC monomers has been developed, enabling the production of products with high purity through a simple work-up process. This method is compatible with various amino acids, and the resulting monomers can undergo normal polymerization reactions. By significantly enhancing the availability of NPC monomers, this method facilitates the synthesis of polypeptides. ? 2024 The Royal Society of Chemistry.