文献类型：期刊文献

英文题名：Lactiplantibacillus plantarum X7022 ameliorates loperamide-induced constipation and modulates gut microbiota in mice

作者：Chen, Xingye[1];Liu, Guang[1];Zhao, Li[1];Du, Lei[1];Xie, Jingli[1,2];Wei, Dongzhi[1,2]

机构：[1]East China Univ Sci & Technol, Sch Biotechnol, Dept Food Sci & Technol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China;[2]Shanghai Collaborat Innovat Ctr Biomfg SCICB, Shanghai, Peoples R China

年份：2022

卷号：1

期号：3-4

起止页码：252

外文期刊名：FOOD BIOENGINEERING

收录：EI(收录号：20232414215002);WOS:【ESCI(收录号:WOS:001328267800001)】；

基金：Natural Science Foundation of Shanghai, Grant/Award Number: 21ZR1416200; National Key Research and Development Program of China, Grant/Award Number:2020YFA0907800r No Statement Available

语种：英文

外文关键词：constipation; gut microbiota; Lactiplantibacillus plantarum X7022

摘要：Lactiplantibacillus plantarum X7022 is a novel strain isolated from stinky tofu brine. Its constipation amelioration potential was evaluated on two different constipation types (acute and subacute) in mice induced by loperamide hydrochloride in present work. L. plantarum X7022 could significantly decrease the first black stool defecation time, and increase black fecal weight, number, and the gastrointestinal transit ratio in both models. High-dose treatment of L. plantarum X7022 (2 x 10(10) CFU/kg BW) was more significant in improving constipation condition than low-dose (2 x 10(7) CFU/kg BW). Furthermore, 16S rDNA sequencing of the intestinal flora showed that the treatment with the strain X7022 could increase the alpha diversity in both constipation models. Meanwhile, the abundance of Bacteroidetes increased, and Firmicutes decreased, which was more effective in acute constipated mice. In addition, X7022 treatment could enhance the relative abundance of beneficial flora, such as Bacteroides, Ruminococcus, and depressed Adlercreutzia and Odoribacter in acute model mice. In subacute constipated mice, X7022 treatment could enhance Alloprevotell, Rikenellaceae_RC9, and decreased Lachnospiraceae_NK4A136 and Desulfovibrio. Therefore, L. plantarum X7022 is a prospect probiotic strain for the amelioration of constipation.