文献类型：期刊文献

英文题名：A Light-Operated Molecular Cable Car for Gated Ion Transport

作者：Wang, Chenxi[1,2];Wang, Shunkang[1,2];Yang, Huiting[1,2];Xiang, Yanxin[1,2];Wang, Xuebin[1,2];Bao, Chunyan[1,2];Zhu, Linyong[1,2];Tian, He[1,2];Qu, Da-Hui[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Sch Chem & Mol Engn,Inst Fine Chem, Feringa Nobel Prize Scientist Joint Res Ctr,Front, Shanghai 200237, Peoples R China

年份：2021

卷号：60

期号：27

起止页码：14836

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20211910312534);WOS:【SCI-EXPANDED(收录号:WOS:000647992500001)】；

基金：This work was supported by the National Key Research and Development Project (2019YFA0110500), NSFC/China (22025503, 21790361 and 21871084), Shanghai Municipal Science and Technology Major Project (grant 2018SHZDZX03), the Fundamental Research Funds for the Central Universities, the Programme of Introducing Talents of Discipline to Universities (grant B16017), Program of Shanghai Academic/Technology Research Leader (19XD1421100). We thank Dr. Chengxi Zhao for his help in the calculation of molecular structure optimization. We thank the Research Centre of Analysis and Test of East China University of Science and Technology for the help with the characterization.

语种：英文

外文关键词：artificial ion transport; host– guest system; light-gating; molecular machine; rotaxanes

摘要：Inspired by the nontrivial and controlled movements of molecular machines, we report an azobenzene-based molecular shuttle PR2, which can perform light-gated ion transport across lipid membranes. The amphiphilicity and membrane-spanning molecular length enable PR2 to insert into the bilayer membrane and efficiently transport K+ (EC50=4.1 mu m) through the thermally driven stochastic shuttle motion of the crown ether ring along the axle. The significant difference in shuttling rate between trans-PR2 and cis-PR2 induced by molecular isomerization enables a light-gated ion transport, i.e., ON/OFF in situ regulation of transport activity and single-channel current. This work represents an example of using a photoswitchable molecular machine to realize gated ion transport, which demonstrates the value of molecular machines functioning in biomembranes.