文献类型：专利

英文题名：Preparing phlegm eliminating medicine ambroxol key intermediate trans-4-((2-amino benzyl)amino)-cyclohexanol comprises condensing nitrobenzaldehyde and trans-4-amino cyclohexanol, and carrying out catalytic hydrogenation and reduction

作者：WANG C;WANG Y;LIU Q;LIU A;JI Y;JIANG J;YU Y

机构：[1]UNIV EAST CHINA SCI&TECHNOLOGY;[2]SHANDONG HAOYUAN IND GROUP CO LTD;[3]UNIV EAST CHINA SCI & TECHNOLOGY

申请号：CN102050748-B

公开日：2013-08-28

语种：英文

收录：DERWENT

摘要：NOVELTY - Preparing phlegm eliminating medicine ambroxol key intermediate trans-4-((2-amino benzyl)amino)-cyclohexanol comprises condensing nitrobenzaldehyde and trans-4-amino cyclohexanol to obtain (E)-4-(2-nitrobenzylideneamino)cyclohexanol and carrying out catalytic hydrogenation and reduction of (E)-4-(2-nitrobenzylideneamino)cyclohexanol in an one-pot boiling reaction way to obtain trans-4-((2-amino benzyl)amino)-cyclohexanol. USE - The method is useful for preparing phlegm eliminating medicine ambroxol key intermediate trans-4-((2-amino benzyl)amino)-cyclohexanol. ADVANTAGE - The method provides trans-4-((2-amino benzyl)amino)-cyclohexanol with high yield, is simple and suitable for large scale production, utilizes low cost raw materials and has moderate reaction conditions.