文献类型：期刊文献

英文题名：Metastable characteristic of erythromycin solventing-out crystallization process

作者：Chen, Kui[1]; Zhu, Jia-Wen[1]; Ji, Li-Jun[1]; Wu, Bin[1]

机构：[1] Chemical Engineering Research Center, East China University of Science and Technology, Shanghai 200237, China

年份：2006

卷号：20

期号：5

起止页码：847

外文期刊名：Gao Xiao Hua Xue Gong Cheng Xue Bao/Journal of Chemical Engineering of Chinese Universities

收录：EI(收录号：20064910289729)

语种：英文

外文关键词：Acetone - Crystallization - Grain growth - Grain size and shape - Solubility - Water

摘要：In industry, the erythromycin is usually produced by the method of solventing-out crystallization. The metastable characteristic of erythromycin solventing-out process directly influences the granularity and crystal size distribution of the product. In the present work, the metastable zone width of erythromycin was studied, where the gravimetric method was employed to measure the erythromycin solubility in water-acetone solution, and the laser scattering method was used to determine its supersolubility. The investigation indicates that the erythromycin solubility in water-acetone solution reduces with decreasing temperature, and all solubility curves with temperatures below 32°C would tend to converge on a certain point. The metastable zone width of erythromycin narrows down with the decrease of the acetone concentration, and the minimum width will be reached when the mass ratio of MWater/MAcetone is about 1.7 at 50°C. Supersolubility curves drop obviously when the water adding rate is increased. The metastable zone width at 50°C changes with the variation of stirring speed and reaches its minimum when the stirring speed is 340 r·min-1. Based on the above studies, a novel alternatively controlled crystallization process was proposed, in which the high temperature and high stirring intensity are taken for the beginning of the crystallization, and then a lower temperature and lower stirring intensity are used to extend the growth of the crystals. The alternatively controlled solventing-out crystallization process proposed can favor the formation of crystals with apparently larger crystal size and homogeneous size distribution, and the product with high specific activity can thus be obtained.