文献类型：期刊文献

英文题名：Enantioselective Conjugate Addition of N-Heterocycles to α,β-Unsaturated Ketones Catalyzed by Chiral Primary Amines

作者：Luo, Guangshun[1];Zhang, Shilei[1];Duan, Wenhu[1,2];Wang, Wei[1,3]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut Sci, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Shanghai Inst Materia Med, Shanghai 201203, Peoples R China;[3]Univ New Mexico, Dept Chem & Biol Chem, Albuquerque, NM 87131 USA

年份：2009

期号：9

起止页码：1564

外文期刊名：SYNTHESIS-STUTTGART

收录：;EI(收录号：20092912194979);WOS:【SCI-EXPANDED(收录号:WOS:000266334000022)，CCR-EXPANDED(收录号:WOS:000266334000022)】；

基金：We are grateful for financial support from the School of Phannacy, East China University of Science & Technology and the National Science Foundation of China (080103 1005), and the National Science Foundation (CHE-0704015).

语种：英文

外文关键词：primary amines; N-heterocycles; enones; conjugate addition; catalysis

摘要：A new organocatalytic enantioselective conjugate addition reaction of nitrogen-centered heterocycles with alpha,beta-unsaturated ketones has been developed. Promoted by a chiral cinchona alkaloid derived primary amine, the reaction affords the adducts ill moderate to high enantioselectivities.