文献类型：期刊文献

英文题名：An Artificial Molecular Shuttle Operates in Lipid Bilayers for Ion Transport

作者：Chen, Sujun[1,2];Wang, Yichuan[1,2];Nie, Ting[1,2];Bao, Chunyan[1,2];Wang, Chenxi[1,2];Xu, Tianyi[1,2];Lin, Qiuning[1,2];Qu, Da-Hui[1,2];Gong, Xueqing[1,2];Yang, Yi[3];Zhu, Linyong[1,2];Tian, He[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Optogenet & Synthet Biol Interdisciplinary Res Ct, State Key Lab Bioreactor Engn, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2018

卷号：140

期号：51

起止页码：17992

外文期刊名：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录：;EI(收录号：20185006243439);WOS:【SCI-EXPANDED(收录号:WOS:000454751800027)】；

基金：This work was supported by NSFC/China (21472044, 21425311, 21790361, 21421004), Shanghai Municipal Science and Technology Major Project (Grant No. 2018SHZDZX03), the Fundamental Research Funds for the Central Universities (222201717003), and the Program of Introducing Talents of Discipline to Universities (B16017).

语种：英文

外文关键词：Molecular electronics - Ion exchange - Ions - Stochastic systems

摘要：Inspired by natural biomolecular machines, synthetic molecular-level machines have been proven to perform well-defined mechanical tasks and measurable work. To mimic the function of channel proteins, we herein report the development of a synthetic molecular shuttle, [2]rotaxane 3, as a unimolecular vehicle that can be inserted into lipid bilayers to perform passive ion transport through its stochastic shuttling motion. The [2]rotaxane molecular shuttle is composed of an amphiphilic molecular thread with three binding stations, which is interlocked in a macrocycle wheel component that tethers a K+ carrier. The structural characteristics enable the rotaxane to transport ions across the lipid bilayers, similar to a cable car, transporting K+ with an EC50 value of 1.0 mu M (3.0 mol % relative to lipid). We expect that this simple molecular machine will provide new opportunities for developing more effective and selective ion transporters.