文献类型：期刊文献

英文题名：Diselenide-containing poly(Ε-caprolactone)-based thermo-responsive hydrogels with oxidation and reduction-triggered degradation

作者：Zhang, Yan[1]; Xu, Ying[1]; Wei, Chao[1]; Zhang, Yuanying[1]; Yang, Liu[1]; Song, Zhongchen[2]; Lang, Meidong[1]

机构：[1] Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China; [2] Department of Periodontology, Ninth of People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China

年份：2017

卷号：4

起止页码：172

外文期刊名：Materials Today Chemistry

收录：EI(收录号：20184506044927)

语种：英文

外文关键词：Controlled drug delivery - Oxidation - Temperature - Selenium compounds - Targeted drug delivery

摘要：Herein, novel multi-responsive injectable polyester hydrogels were reported based on the diselenide-containing poly(Ε-caprolactone) copolymers ((mPEG-PCL-Se)2). The (mPEG-PCL-Se)2 solution remained a free-flowing state at ambient temperature but spontaneously turned into a semisolid hydrogel upon heating to physiologic temperature. The phase transition temperature was examined to be dependent on the composition and aqueous concentration of the copolymers. More importantly, the thermo-responsive hydrogels were endowed with oxidation and reduction-triggered degradation by the incorporation of diselenide groups. Accordingly, the degradation of poly(Ε-caprolactone)-based hydrogels was greatly improved and the rate of degradation was well regulated by the concentration of hydrogen peroxide (H2O2) or glutathione (GSH). This superior stimuli-responsive degradation could lead to an enhanced drug release of encapsulated drug (Doxorubicin, DOX). Thus the oxidation and reduction-triggered degradable diselenide-containing poly(Ε-caprolactone) hydrogels would offer great potential for the controlled drug delivery. ? 2017