文献类型：期刊文献

英文题名：A dual-modality hydrogen sulfide-specific probe integrating chemiluminescence with NIR fluorescence for targeted cancer imaging

作者：Dong, Xuemei[1,2];Sun, Lixin[1,2];Zhang, Ziwen[3];Zhu, Tianli[1,2];Sun, Jie[1,2];Gao, Jinzhu[1,2];Dong, Chengjun[1,2];Wang, Rongchen[1,2];Gu, Xianfeng[3];Zhao, Chunchang[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai 201203, Peoples R China

年份：2023

卷号：66

期号：6

起止页码：1869

外文期刊名：SCIENCE CHINA-CHEMISTRY

收录：;EI(收录号：20231914076686);WOS:【SCI-EXPANDED(收录号:WOS:000983882900004)】；

基金：AcknowledgementsThis work was supported by the National Natural Science Foundation of China (22077030, 22271092, 21977018, 82173657), and the China Postdoctoral Science Foundation (2021M701196). We appreciate Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization.

语种：英文

外文关键词：chemiluminescence; fluorescence; BODIPY; dual-modal imaging; H2S

摘要：Taking apart in numerous physiological and pathological activities, hydrogen sulfide (H2S) has been selected as an excellent target spot for the early diagnosis of cancer. So far, there are many mature probes that apply single optical imaging to monitor endogenous H2S. Nevertheless, a single modality is not an ideal method to afford accurate diagnostic information in comprehensive biological organisms. Herein, we developed a dual-modal imaging probe BWS. This designed probe showed a specific response to H2S with both chemiluminescence and NIR fluorescence light-up. The concurrence of fluorescence and chemiluminescence signal provided "double insurances" for highly accurate monitoring of H2S. Satisfactorily, this dual-modal imaging probe performed precise visualization of endogenous H2S in living cells and in vivo. We envisaged that this chemiluminescence/fluorescence real-time dual-modality strategy for H2S detection will expand and optimize the multimodal imaging methods for efficient diagnosis and treatment of cancer.