文献类型：期刊文献

英文题名：Tumor Microenvironment-Responsive Polymer Delivery Platforms for Cancer Therapy

作者：Shi, Yiqi[1,2];Yu, Qianqian[1,2];Tan, Lijie[3];Wang, Qi[1,2];Zhu, Wei-Hong[1,2,4]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Key Lab Adv Mat,Shanghai Key Lab Funct Mat Chem,Fe, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem,Feringa Nobel Priz, Shanghai 200237, Peoples R China;[3]Fudan Univ, Zhongshan Hosp, Canc Ctr, Dept Thorac Surg, Shanghai, Peoples R China;[4]East China Univ Sci & Technol, Ctr Photosensit Chem Engn, Shanghai 200237, Peoples R China

年份：2025

卷号：64

期号：26

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20251718301572);WOS:【SCI-EXPANDED(收录号:WOS:001474952800001)】；

基金：This work was supported by National Key Research and Development Program of China (2021YFA0910000, 2024YFA1803501), Basic Science Center of NSFC (T2488302), NSFC Excellent Young Scientist (EYS) Scheme (22222803), Science and Technology Commission of Shanghai Municipality (24DX1400200), National Natural Science Foundation of China (92356301, 22338006).

语种：英文

外文关键词：Cancer diagnosis and therapy; Drug delivery and release; Polymer vector design; Responsive molecular design; Tumor microenvironment-responsive linkers

摘要：Most chemotherapeutic and bioimaging agents struggle with inadequate bioavailability, primarily due to their limited biocompatibility and lack of specificity in targeting, leading to low or decreased anticancer efficacy and inaccurate imaging. To surmount these obstacles, the development of stimuli-responsive polymer delivery platforms, predominantly leveraging the tumor microenvironment (TME), has emerged as a promising strategy. Therapeutic and diagnostic agents can be released controllably at the tumor site by virtue of the bond cleavage or hydrophobic to hydrophilic transformation of TME-sensitive linkages in TME-responsive systems, thus augmenting cancer treatment and imaging precision, while simultaneously attenuating the damage to healthy tissues and false imaging signals caused by non-specific drug leakage. In this comprehensive review, we scrutinize recent studies of TME-responsive polymer delivery platforms, encompassing pH-, ROS-, GSH-, enzyme-, and hypoxia-responsive vectors, significantly from the perspective of their molecular design and responsive mechanism, and further summarizing their bio-application in drug delivery and diagnostic imaging. Moreover, this review encapsulates the critical challenges and offers an insightful perspective on the future prospects of TME-responsive polymer delivery platforms in terms of molecular and vector design.