文献类型：期刊文献

英文题名：Rolling "wool-balls": rapid live-cell mapping of membrane sialic acids via poly-p-benzoquinone/ethylenediamine nanoclusters

作者：Chen, Bin-Bin[1];Wang, Xiao-Yuan[1];Qian, Ruo-Can[1]

机构：[1]East China Univ Sci & Technol, Res Ctr, Sch Chem & Mol Engn, Key Lab Adv Mat & Feringa Nobel Prize Scientist J, Shanghai 200237, Peoples R China

年份：2019

卷号：55

期号：65

起止页码：9681

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000479314800018)】；

基金：This research was supported by the National Natural Science Foundation of China (21605048), the National Science and Technology Major Project of China (2018ZX10302205), the Natural Science Foundation of Shanghai (19ZR1472300) and the Chenguang Program (16CG35).

语种：英文

摘要：Here, we report a convenient, fast labeling strategy for the imaging of cell surface sialic acids (SAs, nine-carbon monosaccharides located at the terminals of cell surface sugar chains). This strategy is based on the synthesis of sticky, furry and fluorescent "wool-balls", which are wound into nanoclusters from p-benzoquinone/ethylenediamine polymer "wires". With abundant amino groups at the surface, the wool-balls can easily stick to the C-7 aldehyde group generated at the ends of periodate treated SAs in less than 30 min.