文献类型：期刊文献

英文题名：Synthesis and Self-Assembly Behavior of Amphiphilic Polypeptide-Based Brush-Coil Block Copolymers

作者：Cai, Chunhua[1];Zhu, Wenjie[1];Chen, Tao[1];Lin, Jiaping[1];Tian, Xiaohui[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2009

卷号：47

期号：22

起止页码：5967

外文期刊名：JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

收录：;EI(收录号：20094412411353);WOS:【SCI-EXPANDED(收录号:WOS:000271670000004)】；

基金：This work was supported by National Natural Science Foundation of China (50673026). Supports from Projects of Shanghai Municipality (09XD1401400, 082231, 0952nm05100, B502, and 08DZ2230500) are also appreciated.

语种：英文

外文关键词：amphiphilics; brush copolymer; micelles; polypeptide; self-assembly

摘要：Synthesis and self-assembly behavior of a novel amphiphilic brush-coil block copolymer bearing hydrophilic poly(ethylene glycol) segment and hydrophobic polypeptide brush segment were presented in this work. The poly(gamma-benzyl-L-glutamate) (PBLG) brush is synthesized through "grafting from" strategy by ring-opening polymerization of gamma-benzyl-L-glutamate-N-carboxyanhydride (BLG-NCA) initiated by the flanking terminal primary amino group of macroinitiator. The copolymers were characterized by H-1 NMR, gel permeation chromatography, Fourier transform infrared, circular dichroism spectrum, and differential scanning calorimetry. The self-assembly behavior of the brush-coil block copolymers in aqueous solution was investigated by means of transmission electron microscopy, scanning electron microscopy, atomic force microscopy, and laser light scattering. Spherical micelles were observed when the length of PBLG brush is shorter. The aggregate morphology transforms to spindle-like micelles and then to rod-like micelles, as the length of polypeptide brush increases. (C) 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 5967-5978, 2009