文献类型：期刊文献

英文题名：Polysaccharide isolated fromAuricularia auricular-judae (Bull.)prevents dextran sulfate sodium-induced colitis in mice through modulating the composition of the gut microbiota

作者：Zhao, Di[1];Dai, Wenjing[1];Tao, Heng[1];Zhuang, Wei[1];Qu, Mi[1];Chang, Ya-Ning[1]

机构：[1]East China Univ Sci & Technol, Sch Biotechnol, State Key Lab Bioreactor Engn, .130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2020

卷号：85

期号：9

起止页码：2943

外文期刊名：JOURNAL OF FOOD SCIENCE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000551295100001)】；

语种：英文

外文关键词：colitis; fecal microbiota transplantation; gut microbiota; high-throughput sequencing; polysaccharide

摘要：Inflammatory bowel disease (IBD) is a chronic intestinal disease, which was commonly found in westerners whereas is increasingly prevalent in Asia because of the changing eating habits. In previous research, we found that a water-soluble polysaccharide isolated fromAuricularia auricular-judae (Bull.)-a kind of edible mushroom (Aap)-is composed of beta-1,3 glycosidic bonds, which is regarded as therapeutic or protective substance in enteritis. We therefore aimed to find the preventing effect of Aap on IBD. Here, we reported that pre-administration of Aap not only ameliorated weight loss, colon damage, and mucosal inflammation in colitis mice, but also prevented the damage of intestinal barrier by reducing the D-lactic acid and diamine oxidase level in plasma. Through high-throughput sequencing, we found that Aap changed gut microbiota composition. Furthermore, the preventing effect was transmissible via horizontal feces transfer from Aap-treated mice to normal mice. Our results indicated that oral administration of Aap is a promising protective substance of IBD. Practical Application Our study proved thatAuricularia auriculapolysaccharide had substantial preventing effect on DSS-induced colitis in mice. This research might lay the theoretical foundation and technical support for the development of related functional foods. People could also enhance their gut immunity by eatingAuricularia auricularin their daily life.Auricularia auricularas a highly nutritious agricultural product showed the broad significance in nutrition and food function.