文献类型：期刊文献

英文题名：Polyetheretherketone/nano-fluorohydroxyapatite composite with antimicrobial activity and osseointegration properties

作者：Wang, Lixin[1];He, Shu[2,4];Wu, Xiaomian[3,4];Liang, Shanshan[5];Mu, Zhonglin[5];Wei, Jie[6];Deng, Feng[3];Deng, Yi[4];Wei, Shicheng[2,3,4]

机构：[1]Capital Med Univ, Beijing Shijitan Hosp, Dept Stomatol, Beijing 100038, Peoples R China;[2]Peking Univ, Sch & Hosp Stomatol, Lab Interdisciplinary Studies, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China;[3]Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China;[4]Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China;[5]Hainan Med Coll, Affiliated Hosp, Hainan 571199, Peoples R China;[6]E China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2014

卷号：35

期号：25

起止页码：6758

外文期刊名：BIOMATERIALS

收录：;EI(收录号：20142417821613);WOS:【SCI-EXPANDED(收录号:WOS:000338386800010)】；

基金：This work was supported by National Natural Science Foundation of China (Grant 30973317), Natural Science Foundation of Hainan Province (813191), Key Science and Technology Plan Projects of Hainan Province (ZDXM20110051), and Peking University's 985 Grant.

语种：英文

外文关键词：Polyetheretherketone; Fluorohydroxyapatite; Antimicrobial; Bioactivity; Osseointegration; Implant

摘要：Lack of antibacterial activity and binding ability to natural bone tissue has significantly limited polyetheretherketone (PEEK) for many challenging dental implant applications. Here, we have developed a polyetheretherketone/nano-fluorohydroxyapatite (PEEK/nano-FHA) biocomposite with enhanced antibacterial activity and osseointegration through blending method. Smooth and rough surfaces of PEEK/nano-FHA biocomposites were also prepared. Our results showed that in vitro initial cell adhesion and proliferation on the nano-FHA reinforced PEEK composite were improved. In addition, higher alkaline phosphatase activity and cell mineralization were also detected in cells cultured on PEEK/nano-FHA biocomposites, especially for rough PEEK/nano-FHA surfaces. More importantly, the as-prepared PEEK/nano-FHA biocomposite could effectively prevent the proliferation and biofilm formation of bacterial. For in vivo test, the newly formed bone volume of PEEK/nano-FHA group was higher than that of bare PEEK group based on 3D microcomputed tomography and 2D histomorphometric analysis. These reports demonstrate that the developed PEEK/nano-FHA biocomposite has increased biocompatibility and antibacterial activity in vitro, and promoted osseointegration in vivo, which suggests that it holds potential to be applied as dental implant material in dental tissue engineering applications. (C) 2014 Elsevier Ltd. All rights reserved.