文献类型：期刊文献

英文题名：Metal-free directed C-H borylation of 2-(N-methylanilino)-5-fluoropyridines and 2-benzyl-5-fluoropyridines

作者：Wu, Gaorong[1,2];Xu, Xiaobo[1,2];Wang, Shuai[1,2];Chen, Lu[1,2];Pang, Binghan[1,2];Ma, Tao[3];Ji, Yafei[1,2]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[3]Beijing Univ Chinese Med, Sch Chinese Mat Med, Liangxiang Campus, Beijing 102488, Peoples R China

年份：2022

卷号：33

期号：4

起止页码：2005

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000789375500051)，CCR-EXPANDED(收录号:WOS:000789375500051)】；

语种：英文

外文关键词：Metal-free; C-H borylation; 2-(N-Methylanilino)-5-fluoropyridines; 2-Benzyl-5-fluoropyridines; BBr3

摘要：A novel method for metal-free C-H borylation of 2-(N-methylanilino)-5-fluoropyridines and 2-benzyl-5-fluoropyridines has been reported. The 5-fluoropyridine directed borylation reaction exhibited high efficiency and site exclusivity. The useful protocol could be executed on a gram-scale easily and the borylated products showed good derivatization applications. Moreover, the practicality of the strategy was expanded by the fact that the directing group could be removed in an acceptable yield. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.