文献类型：期刊文献

英文题名：Progress and perspective of trained immunity in teleost fish

作者：You, Xinwei[1];Yang, Jin[1];Wang, Zhuang[1];Wang, Qiyao[1];Liu, Qin[1];Zhang, Yuanxing[1];Wiegertjes, Geert F.[2];Yang, Dahai[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Lab Aquat Anim Dis, Shanghai 200237, Peoples R China;[2]Wageningen Univ & Res, Aquaculture & Fisheries Grp, NL-6708 WD Wageningen, Netherlands

年份：2024

卷号：16

期号：2

起止页码：732

外文期刊名：REVIEWS IN AQUACULTURE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001076441500001)】；

基金：We apologize to authors whose work could not be referenced in this review due to space limitations. The figure was created using . This work was supported by the grants of National Natural Science Foundation of China (32122090, Dahai Yang), the National Key Research and Development Program of China (2022YFD2402000, Dahai Yang) and the Fundamental Research Funds for the Central Universities (222201211626).

语种：英文

外文关键词：effector cell; longer-term protection; molecular mechanism; teleost fish; trained immunity

摘要：Trained immunity defines the long-term memory of innate immunity based on innate immune signalling, metabolic changes and epigenetic rewiring of trained innate immune cells, which are characterised by elevated inflammatory responses towards secondary stimuli. The activation of this non-specific protection-mediated memory in innate immune cells was identified to benefit host defences as well as play a detrimental role in inflammatory diseases. In this review, we focused on summing up the current progress about the inducers, effector cells, molecular mechanisms and protective effects of trained immunity that have been identified in both mammals and teleost fish, and discussing the future research and application of trained immunity in aquaculture. Revealing the mechanisms of trained immunity will not only provide a novel aspect for understanding the evolution of innate immune memory and their longer-term protections, but also contribute to the rational design and evaluation of immunopotentiators, adjuvants and potential vaccines in aquaculture.