文献类型：期刊文献

英文题名：Micro-3D printed Concanavalin A hydrogel based photonic devices for high-sensitivity glucose sensing

作者：Wei, Heming[1];Han, Long[1];Yin, Ruixue[2];Yang, Tian[3];Liu, Yunqi[1];Mou, Chengbo[1];Pang, Fufei[1];Wang, Tingyun[1]

机构：[1]Shanghai Univ, Key Lab Specialty Fiber Opt & Opt Access Networks, Joint Int Res Lab Specialty Fiber Opt & Adv Commun, Shanghai 200444, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Intelligent Sensing & Detect, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Elect Informat & Elect Engn, State Key Lab Adv Opt Commun Syst & Networks, Key Lab Thin Film & Microfabricat Minist Educ, Shanghai 200240, Peoples R China

年份：2023

卷号：386

外文期刊名：SENSORS AND ACTUATORS B-CHEMICAL

收录：;EI(收录号：20231413833303);WOS:【SCI-EXPANDED(收录号:WOS:000979521300001)】；

基金：This work was supported by the National Natural Science Foundation of China (62005153) and partly by the Natural Science Foundation of Shanghai, China (20ZR1420300) . R. Y. would like to thank Shanghai key laboratory of intelligent sensing and detection for supporting this work.

语种：英文

外文关键词：Glucose detection; Long period fiber grating; 3D printing; Hydrogel sensor; Optical fiber sensor

摘要：Concanavalin A (Con A)-based hydrogels have been widely studied in the field of glucose detection as Con A can selectively bond to glucose molecules. Many sensors have been proposed for detecting glucose using fluorescence or optical methods. However, these sensors suffer from limited sensitivity and fabrication issues. In this study, a label-free optical-fiber long-period grating-based glucose sensor is proposed. Con A-based UV-curable hydrogel was used as the sensing material, which can be rapidly prototyped using the micro-3D printing technique to realize microscale structures. Polymerized hydrogel grating structures patterned onto the fiber surface can periodically modulate the refractive index of the fiber modes affecting the resonant spectrum of the device. The structures swelled upon the addition of a glucose solution, which caused a wavelength shift in the transmission spectrum. The experiments showed that glucose-induced swelling/deswelling was reversible, and the wavelength versus glucose concentration was linear with a response sensitivity of 0.206 nm/mM over a wide range of 0-25 mM with high linearity (R2 = 0.998). The device works well at room temperature and has a short response time. It has significant potential for use in real time continuous glucose monitoring.