文献类型：期刊文献

英文题名：Pvp-I Catalyzed Oxidation of Benzylamines to Aryl Formamides

作者：Lu, Guangying[1,2]; Yuan, Xinxin[1]; Wang, Jian[1]; Sun, Xue-Qin[1]; Cao, Fu-Rong[1]; Ren, Jiangmeng[1]; Ke, Yanxiong[2]; Mu, Xin[2]; Bu-Bing, Zeng[1,2]

机构：[1] Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, China; [2] Engineering Research Centre of Pharmaceutical Process Chemistry, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China

年份：2023

外文期刊名：SSRN

收录：EI(收录号：20230142379)

语种：英文

外文关键词：Amides

摘要：An oxidative transformation from substituted benzylamine into the corresponding aryl formamides was developed here using the oxidative system combined from the catalytic amount of PVP-I with TBHP. This newly developed method had the advantages of mild reaction conditions and broad substrate scope. The key intermediate of Enzalutamide as androgen receptor inhibitors was prepared using this catalytic condition starting from commercial available 2-fluoro-4-nitrobenzaldehyde with the yield of 61% for three-step reactions. ? 2023, The Authors. All rights reserved.