文献类型：期刊文献

英文题名：An electrochemical sensor employing ?-cyclodextrin chiral cross-linked metal organic framework and graphene oxide for chiral enantiomer recognition

作者：Sun, Xuezhi[1];Fu, Zhibo[1];Zhang, Min[2];Fu, Hua[3];Lin, Chuhui[1];Kuang, Jingjing[1];Zhang, Hongyang[1];Hu, Ping[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Sch Pharm, Shanghai 200237, Peoples R China;[3]Qinghai Univ, Sch Chem Engn, Xining 810016, Peoples R China

年份：2022

卷号：183

外文期刊名：MICROCHEMICAL JOURNAL

收录：;EI(收录号：20220340055);WOS:【SCI-EXPANDED(收录号:WOS:000882067900001)】；

语种：英文

外文关键词：?-Cyclodextrin; Cross -linked MOFs; Graphene oxide; Electrochemical sensor; Chiral recognition; Mandelic acid

摘要：Chirality is a universal feature of nature, and the effective differentiation of chiral molecules is still a challenge. Here we propose a method for recognizing chiral molecules based on an electrochemical detection method. We use beta-cyclodextrin as an organic ligand and coordinate it with K ions to form a metal-organic framework (MOF), then we use diphenyl carbonate to connect MOFs to obtain chiral Cross-Linked MOF (CLMOF). This CLMOF is different from the cyclodextrin MOFs reported in previous literature in that it can maintain a stable structure in the aqueous environment. CLMOF and graphene oxide (GO) are jointly modified on the glassy carbon electrode (GCE) surface to build a GO-CLMOF/GCE electrochemical sensor which is used for the chiral recognition of the enantiomers of mandelic acid (MA). The DL enantiomers of MA exhibit different electrochemical behaviors on the GO-CLMOF/GCE sensor. Their peak current ratio (IL/ID) reaches 1.8, and the peak potential difference Delta E (ED-EL) is 96 mV. It shows good linearity in the range of 0.5-30 mM. The detection limits of D-MA and L-MA are 0.15 mM and 0.09 mM, respectively. The method was successfully applied to the detection of DL-MA enantiomer of unknown concentration in urine. The recognition of DL enantiomers on the electrode surface is possible because DL-MA forms diastereomers with CLMOF. The electrochemical sensor made of CLMOF and GO is simple to prepare and has excellent selectivity for DL enantiomers of MA, and provides a possible idea for the identification and quantification of chiral isomers.