文献类型：专利

英文题名：Manufacture of pyrrole-containing compound involves reacting aldehyde group-containing compound and hydroxypyrrolidine-2-carboxylic acid in presence of acid catalyst

作者：XU H;XU Z;LUO T;YU X;ZHANG M;ZOU Z;DENG Z

机构：[1]UNIV EAST CHINA SCI&TECHNOLOGY

申请号：CN102180824-A

申请日：2011-02-18

公开日：2011-09-14

语种：英文

收录：DERWENT

摘要：NOVELTY - An aldehyde group-containing compound (I) reacts with (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid in presence of an acid catalyst to obtain pyrrole-containing compound (II). USE - Manufacture of pyrrole-containing compound. ADVANTAGE - The method efficiently provides high yield of pyrrole-containing compound by simple method. DETAILED DESCRIPTION - An aldehyde group-containing compound of formula: Ar'-CHO (I) reacts with (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid in presence of an acid catalyst to obtain pyrrole-containing compound of formula (II). Ar'=5 or 6 membered aromatic ring or 5 or 6 membered hetero aromatic ring having 1-3 heteroatom(s) chosen from N, O or S (both optionally substituted by halo, nitro, hydroxy, cyano or alkoxy).