文献类型：期刊文献

英文题名：A biomimetic and bioactive scaffold with intelligently pulsatile teriparatide delivery for local and systemic osteoporosis regeneration

作者：Che, Lingbin[1];Wang, Ying[2,3];Sha, Dongyong[2,3];Li, Guangyi[4];Wei, Ziheng[1];Liu, Changsheng[2,3];Yuan, Yuan[2,3];Song, Dianwen[1]

机构：[1]Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Orthoped, Sch Med, Shanghai 200080, Peoples R China;[2]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[4]Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China

年份：2023

卷号：19

起止页码：75

外文期刊名：BIOACTIVE MATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000788740100003)】；

基金：This work is supported by National Natural Science Foundation of China for Innovative Research Groups (No.51621002) , and Frontiers Science Center for Materiobiology and Dynamic Chemistry (No. JKVD1211002) , and National Natural Science Foundation of China (Nos. 81571828, 31771040, 31971264) .

语种：英文

外文关键词：Precise pulsatile release; Teriparatide; Smart delivery; Osteoporotic bone regeneration

摘要：Osteoporosis is one of the most disabling consequences of aging, osteoporotic fractures and higher risk of the subsequent fractures leading to substantial disability and deaths, indicating both local fractures healing and the early anti-osteoporosis therapy are of great significance. Teriparatide is strong bone formation promoter effective in treating osteoporosis, while side effects limit clinical applications. Traditional drug delivery is lack of sensitive and short-term release, finding a new non-invasive and easily controllable drug delivery to not only repair the local fractures but also improve total bone mass has remained a great challenge. Thus, bioinspired by the natural bone components, we develop appropriate interactions between inorganic biological scaffolds and organic drug molecules, achieving both loaded with the teriparatide in the scaffold and capable of releasing on demand. Herein, biomimetic bone microstructure of mesoporous bioglass, a near-infrared ray triggered switch, thermosensitive liposomes based on a valve, and polydopamine coated as a heater is developed rationally for osteoporotic bone regeneration. Teriparatide is pulsatile released from intelligent delivery, not only rejuvenating osteoporotic bone defect, but also presenting strong systemic anti-osteoporosis therapy. This biomimetic bone carrying novel drug delivery platform is well worth expecting to be a new promising strategy and clinically commercialized to help patients survive from the osteoporotic fracture.