文献类型：期刊文献

英文题名：Nickel-Catalyzed Cross-Coupling of Diarylborinic Acids with Aryl Chlorides

作者：Chen, Xiaofeng[1];Ke, Haihua[1];Zou, Gang[1]

机构：[1]E China Univ Sci & Technol, Dept Fine Chem, Shanghai 200237, Peoples R China

年份：2014

卷号：4

期号：2

起止页码：379

外文期刊名：ACS CATALYSIS

收录：;EI(收录号：20140817347309);WOS:【SCI-EXPANDED(收录号:WOS:000331164000002)】；

基金：We are grateful for financial support provided by the National Science Foundation of China (No. 20972049).

语种：英文

外文关键词：nickel; phosphine; cross coupling; diarylborinic acid; aryl chloride

摘要：A highly efficient nickel/triarylphosphine catalyst system, Ni[P(4-MeOPh)(3)](2)Cl-2/2P(4-MeOPh)(3), has been developed for cross-coupling of diarylborinic acids with a wide range of aryl chlorides. A variety of unsymmetrical biaryl and heterobiaryl compounds with various functional groups and steric hindrance could be obtained in good to excellent yields using 0.5-2 mol % catalyst loadings in the presence of K3PO4 center dot 3H(2)O in toluene. The high atom economy of diarylborinic acids and cost-effectiveness of the nickel/phosphine catalyst system make the cross-coupling truly practical in the production of biaryl fine chemicals. Usefulness of the nickel/phosphine catalyzed cross-coupling of diarylborinic acids with aryl chlorides has been demonstrated in the development of a scalable and economical process for synthesis of 4'-methyl-2-cyanobiphenyl, Sartan biphenyl.