文献类型：期刊文献

英文题名：Doxorubicin-Loaded Micelles Based on Folic Acid Conjugated pH-Dependent Thermo-Sensitive Copolymer: In Vitro and In Vivo Evaluation

作者：Zhao, Hongli[1,2];Tao, Liang[1,2];Yu, Ronghua[1,2];Yuan, Huihui[1,2];Lan, Minbo[1,2,3]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Res Ctr Anal & Test, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2015

卷号：15

期号：8

起止页码：5553

外文期刊名：JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

收录：;EI(收录号：20150300427589);WOS:【SCI-EXPANDED(收录号:WOS:000350268100009)】；

基金：This work was supported by the Science and Technology Commission of Shanghai Municipality (STCSM, contract no. 12nm0501100).

语种：英文

外文关键词：Doxorubicin-Loaded Micelles; Folic Acid; pH-Dependent Thermo-Sensitive; Targeting Drug Delivery; In Vitro; In Vivo

摘要：In this paper, the doxorubicin (DOX)-loaded micelles were prepared based on a novel folic acid conjugated pH-dependent thermo-sensitive copolymer poly(D,L-lactic acid)-b-poly(N-isopropyl methacrylamide-co-N-isopropylmaelic acid-co-10-undecenoic acid) (PLA-PNNUA-FA) constructed to provide an active targeting drug delivery and triggered drug release system. The micelles were able to target tumors through the interaction between folic acid and its receptors which are over-expressed on the tumor cell membrane, and achieved pH-dependent thermo induced drug release in the intracellular mild acidic media such as endosomes and lysosonnes after the micelles enter the cells. The results of cell assays and animal experiments showed that the micelles exhibited obvious tumor penetration efficiency in vivo, also improved DOX cell uptake and cytotoxicity in vitro. It was suggested that copolymer PLA-PNNUA-FA might be a potential targeted drug carrier to deliver chemotherapeutic drugs achieving better efficacy of chemotherapy.