文献类型：期刊文献

英文题名：Light and reductive dual stimuli-responsive PEI nanoparticles: "AND" logic response and controllable release

作者：Huang, Qi[1];Liu, Tao[1];Bao, Chunyan[1];Lin, Qiuning[1];Ma, Meixin[1];Zhu, Linyong[1]

机构：[1]E China Univ Sci & Technol, Inst Fine Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China

年份：2014

卷号：2

期号：21

起止页码：3333

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20142017720168);WOS:【SCI-EXPANDED(收录号:WOS:000336072400019)】；

基金：This work was supported by NSFC (51273064, 21373084), The State Key Development Program for Basic Research of China (2013CB733700), The Program for Professor of Special Appointment (Eastern Scholar), Innovation Program of Shanghai Municipal Education Commission and Fundamental Research Funds for the Central University.

语种：英文

外文关键词：Irradiation - Computer circuits - Sulfur compounds - Targeted drug delivery

摘要："AND" logic responsive polyetherimide (PEI)-based polymers PENS were constituted by attaching the photoresponsive o-nitrobenzyl phototrigger and reductive responsive disulfide linker to the polymer PEI. This dual-responsive system maintained micelle-like assembly upon single photo or reductive stimuli. The disassembly only occurred when photo and reductive signals were input at the same time. This smart system was therefore applied as a carrier for the controlled release of the anti-cancer drug doxorubicin (DOX), which exhibited effective release only when UV irradiation and GSH reduction were applied simultaneously.