文献类型：期刊文献

英文题名：Stereodivergent Pd/Cu catalysis: asymmetric alkylation of racemic symmetrical 1,3-diphenyl allyl acetates

作者：Zhao, Ling[1,2];Li, Guanlin[2];He, Rui[2];Liu, Penglin[2];Wang, Feijun[1];Huo, Xiaohong[2];Zhao, Min[1];Zhang, Wanbin[1,3]

机构：[1]East China Univ Sci & Technol, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Frontiers Sci Ctr Transformat Mol, Sch Chem & Chem Engn, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China;[3]Zhengzhou Univ, Coll Chem & Mol Engn, 75 Daxue Rd, Zhengzhou 450052, Peoples R China

年份：2021

卷号：19

期号：9

起止页码：1955

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20211110079200);WOS:【SCI-EXPANDED(收录号:WOS:000627441700008)，CCR-EXPANDED(收录号:WOS:000627441700008)】；

基金：This work was supported by the Shanghai Sailing Program (19YF1421900), the Shanghai Municipal Education Commission (201701070002E00030), the Science and Technology Commission of Shanghai Municipality (19JC1430100), the China Postdoctoral Science Foundation (2019M663155), and the National Natural Science Foundation of China (21831005, 21901158, and 21991112).

语种：英文

外文关键词：Alkylation

摘要：We report a stereodivergent Pd/Cu catalyst system that was successfully applied to the asymmetric allylic alkylation of symmetrical 1,3-disubstituted allyl acetates with prochiral imino esters, providing efficient access to enantiopure products bearing vicinal stereocenters in a fully stereodivergent manner. The protocol proceeds smoothly under mild reaction conditions and can accommodate a range of imino esters, delivering the substituted products in high yields and with excellent diastereoselectivities (up to >20 : 1 dr) and enantioselectivities (up to >99% ee).