文献类型：期刊文献

中文题名：官能团化聚己内酯的合成与表征

英文题名：SYNTHESIS AND CHARACTERIZATION OF POLY(ε-CAPROLACTONE) BEARING PENDANT FUNCTIONAL GROUPS

作者：戴炜枫[1];何月英[1];黄浩燕[1];郎美东[1]

机构：[1]华东理工大学材料科学与工程学院超细材料制备与应用教育部重点实验室,上海200237

年份：2009

卷号：19

期号：4

起止页码：358

中文期刊名：高分子学报

外文期刊名：Acta Polymerica Sinica

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000265403500010)】；北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

基金：国家自然科学基金(基金号20374013;20674019);上海市曙光计划;上海市科委项目(项目号03JC14023);高等学校博士学科点专项科研基金(基金号20060251015)资助项目

语种：中文

中文关键词：聚己内酯;侧基官能团;生物可降解材料;开环聚合

外文关键词：Poly（ ε-eaprolactone）, Functional group, Biodegradable material, Ring-opening polymerization

摘要：通过分子结构设计合成了新型含有侧基官能团的聚己内酯材料.首先,通过亲核加成反应,由溴乙酸乙酯与烯胺合成2-乙氧甲酰甲基环己酮;然后以间氯过氧化苯甲酸为氧化剂,通过Baeyer-Villiger氧化反应,得到带有官能团的己内酯单体,6-乙氧甲酰甲基-ε-己内酯;该单体在异辛酸亚锡(Sn(Oct)2)的催化下,本体开环聚合得到相应的均聚物及其与ε-己内酯的共聚物.采用1H-NMR、13C-NMR、GPC和DSC表征了聚合物的结构和热力学性能.随着6-乙氧甲酰甲基-ε-己内酯在共聚物中的含量增加,共聚物的分子量降低,同时熔点和熔融焓也随之降低.
Biodegradable aliphatic polyesters such as poly （ glycolide ） （ PGA）, poly （L-lactide） （ PLA ）, poly （ ε- caprolactone） （PCL） and their copolymers have been found widely applications in sutures, tissue engineering, bone fixation and controlled drug delivery due to their excellent bioeompatible and biodegradable properties. But the shortage of functional pendant groups and low hydrophilieity limited their further applications. In this work, we explored a synthetic strategy of aliphatic polyesters functionalized with the pendant carboxylic groups through the ring-opening polymerization of novel funetionalized laetone. First, 2-ethoxycarbonylmethyl-cyclohexanone was synthesized 7;ia nucleophilic addition. Second, 6-ethoxyearbonylmethyl-ε-caprolactone（ECL） was generated by the Baeyer-Villiger oxidation of the 2-ethoxyearbonylmethyl-cyclohexanone. Then, homopolymer and copolymers were accomplished in bulk （130℃） by ring-opening polymerization in the presence of stannous 2-ethyl hexanonate （Sn（Oet）2） as catalyst. All the polymers were characterized by FTIR, ^1H-NMR, ^13C-NMR, GPC, and DSC. The melting temperature （ Tm） decreased with an increase of ECL content because the molecular weight decreased in corresponding. It was also noted that Δ H∞, for eopolymers increased with an increase in the molecular weight because the relative number of copolymer chain ends and pendant functional groups decreased with a decrease of content of ECL.We think the availability of pendent groups on poly（ε-caprolaetone） has great potential for applications in medicine, surgery, and tissue engineering. K