文献类型：期刊文献

英文题名：Electrochemical Confinement Effects for Innovating New Nanopore Sensing Mechanisms

作者：Ying, Yi-Lun[1];Gao, Rui[1];Hu, Yong-Xu[1];Long, Yi-Tao[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China

年份：2018

卷号：2

期号：6

外文期刊名：SMALL METHODS

收录：;EI(收录号：20210609890142);WOS:【SCI-EXPANDED(收录号:WOS:000434982200005)】；

基金：This work was supported by the National Natural Science Foundation of China (21421004, 21327807, and 21711530216), Program of Shanghai Subject Chief Scientist (15XD1501200), and the Fundamental Research Funds for the Central Universities (222201718001, 222201717003, and 222201714012).

语种：英文

外文关键词：electrochemical confinement effects; nanopores; single-molecule detection; wireless nanopore electrodes

摘要：Nanopores employ a confined space for electrochemical sensing of high-throughput individual biomolecules in solution. Tremendous research efforts over the last two decades have made nanopore techniques become a powerful single-molecule tool in nanotechnology and biotechnology. The most general mechanism of nanopore sensing is based on a volume-exclusion effect. However, the increasing demands on revealing the single-molecule chemistry and biophysics require that nanopores not only provide structural/conformational/sequencing information but also directly read the dynamic functional properties of single molecules. Here, the concept of electrochemical confinement effects in nanopores for developing new sensing mechanisms is proposed and extended. Three examples of electrochemical confinement effects are demonstrated here including the confinement of strong interactions between pore and analyte, the electron-transfer process, and the subwavelength light inside nanopores. In particular, the latter two effects lead to novel detection mechanisms beyond volume exclusion, which can efficiently convert the dynamic function/structure of single molecules into ionic signatures or optical patterns. These achievements give rise to the possibility of adopting nanopore sensing in a wider range of future applications in both life and material sciences.