文献类型：期刊文献

中文题名：Celastrol as a tool for the study of the biological events of metabolic diseases

英文题名：Celastrol as a tool for the study of the biological events of metabolic diseases

作者：Gongcai Lan[1,2];Jie Zhang[2];Wenbo Ye[3];Fan Yang[2,4];Ang Li[3,5];Weiwei He[2,5];Wei-Dong Zhang[1,2,4]

机构：[1]Guangdong Pharmaceutical University;[2]Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology;[3]State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences;[4]Department of Phytochemistry, School of Pharmacy, Second Military Medical University;[5]State Key Laboratory of Innovative Natural Medicine and Traditional Chinese Medicine Injections, Jiangxi Qingfeng Pharmaceutical Co.Ltd.

年份：2019

卷号：62

期号：4

起止页码：409

中文期刊名：Science China Chemistry

外文期刊名：中国科学（化学英文版）

收录：Scopus;CSCD:【CSCD2019_2020】；PubMed;

基金：supported by Professor of Chang Jiang Scholars Program, the National Natural Science Foundation of China (81520108030, 21472238, 81502956, 21572064, 21525209, 21621002, 21772225, 21761142003);Chinese Academy of Sciences (Strategic Priority Research Program XDB20000000 and Key Research Program of Frontier Sciences QYZDB-SSW-SLH040);Shanghai Science and Technology Commission (15JC1400400, 17XD1404600);the National Program for Support of Top-Notch Young Professionals of China;the K. C. Wong Education Foundation;the State Key Laboratory of Innovative Natural Medicine and Traditional Chinese Medicine Injections (QFSKL2017003, QFSKL2017004)

语种：英文

中文关键词：celastrol;obesity;type;2;diabetes;endoplasmic;reticulum;stress;inflammation

外文关键词：celastrol;obesity;type 2 diabetes;endoplasmic reticulum stress;inflammation

摘要：Celastrol is a pentacyclic triterpenoid isolated from Tripterygium wilfordii that has long been used in traditional Chinese medicine for treating rheumatoid arthritis. Previous studies showed that celastrol possessed diverse biological activities, including anti-inflammatory and anticancer properties. Interestingly, most recent literatures revealed the important role of celastrol against metabolic disorders. Herein, we provide an overview of the modes of action of celastrol for combating metabolic diseases such as obesity and type 2 diabetes. The anti-obesity effect of celastrol results from relieving endoplasmic reticulum stress in hypothalamus, regulating HSF1-PGC1α axis in the adipose tissue and muscle, and alleviating inflammation via Nur77 mediated autophagy. Celastrol also reverses insulin resistance via NF-κB signaling pathway to protect against type 2 diabetes.
Celastrol is a pentacyclic triterpenoid isolated from Tripterygium wilfordii that has long been used in traditional Chinese medicine for treating rheumatoid arthritis. Previous studies showed that celastrol possessed diverse biological activities, including anti-inflammatory and anticancer properties. Interestingly, most recent literatures revealed the important role of celastrol against metabolic disorders. Herein, we provide an overview of the modes of action of celastrol for combating metabolic diseases such as obesity and type 2 diabetes. The anti-obesity effect of celastrol results from relieving endoplasmic reticulum stress in hypothalamus, regulating HSF1-PGC1α axis in the adipose tissue and muscle, and alleviating inflammation via Nur77 mediated autophagy. Celastrol also reverses insulin resistance via NF-κB signaling pathway to protect against type 2 diabetes.