文献类型：期刊文献

英文题名：Selective cyclization of alkynols and alkynylamines catalyzed by potassium tert-butoxide

作者：Li, Deng Yuan;Shi, Ke Ji;Mao, Xiao Feng;Zhao, Zheng Le;Wu, Xin Yan;Liu, Pei Nian[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2014

卷号：70

期号：39

起止页码：7022

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000341550600016)，CCR-EXPANDED(收录号:WOS:000341550600016)】；

基金：We thank Prof. Guochen Jia in the Hong Kong University of Science & Technology for the generous helps and discussions. This work was supported by the National Natural Science Foundation of China (Project Nos. 21172069, 21190033 and 21372072), the Innovation Program of Shanghai Municipal Education Commission (Project No. 12ZZ050), the Basic Research Program of the Shanghai Committee of Sci. & Tech. (Project No. 13NM1400802), NCET (NCET-13-0798) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Alkynols; Alkynylamines; Potassium tert-butoxide; exo-Cyclic enol ethers; Indoles; Isoindolin-1-ones

摘要：Potassium tert-butoxide (t-BuOK) was found to be an effective catalyst for the cyclization of aromatic alkynols and alkynylamines. In the presence of 10 mol % t-BuOK, a range of alkynols were converted to the corresponding exo-cyclic enol ethers as pure Z-stereoisomers with 100% selectivity and moderate to excellent yields. Moreover, the cyclization of alkynylamines was also achieved to afford indoles and isoindolin-l-ones in good yields. Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.