文献类型：期刊文献

英文题名：Baicalin loaded in folate-PEG modified liposomes for enhanced stability and tumor targeting

作者：Chen, Yiyin[1,2];Le Van Minh[1,2,6];Liu, Jianwen[1,2];Angelov, Borislav[3];Drechsler, Markus[4];Garamus, Vasil M.[5];Willumeit-Roemer, Regine[5];Zou, Aihua[1,2]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[3]Acad Sci Czech Republ, Inst Macromol Chem, Heyrovsky Sq 2, CZ-16206 Prague, Czech Republic;[4]Univ Bayreuth, Bayreuth Inst Macromol Res BIMF, Lab Soft Matter Electron Microscopy, D-95440 Bayreuth, Germany;[5]Helmholtz Zentrum Geesthacht, Ctr Mat & Coast Res, Inst Mat Res, Max Planck Str 1, D-21502 Geesthacht, Germany;[6]Nguyen Tat Thanh Univ, NIT Inst Hitechnol NIH, Ho Chi Minh City, Vietnam

年份：2016

卷号：140

起止页码：74

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20155301742349);WOS:【SCI-EXPANDED(收录号:WOS:000371445500009)】；

基金：Dr. Andreas Meyer, University of Hamburg, is acknowledged for the SAXS measurements. Borislav Angelov acknowledges support from GACR project 15-10527J. We gratefully acknowledge the support of this work by Shanghai Natural Science Foundation (Grant No. 15ZR1409900), the National Natural Science Foundation of China (No. 21573070), and Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Baicalin; Liposomes; Folate receptor; Cryo-TEM; SAXS; Targeting drug delivery

摘要：Bioavailability of baicalin (BAI), an example of traditional Chinese medicine, has been modified by loading into liposome. Several liposome systems of different composition i.e., lipid cholesterol (L), long-circulating stealth liposome (L-PEG) and folate receptor (FR)-targeted liposome (L-FA) have been used as the drug carrier for BAI. The obtained liposomes were around 80 nm in diameter with proper zeta potentials about -25 mV and sufficient physical stability in 3 months. The entrapment efficiency and loading efficiency of BAI in the liposomes were 41.0-46.4% and 8.8-10.0%, respectively. The morphology details of BAI lipsosome systems i.e., formation of small unilamellar vesicles, have been determined by cryogenic transmission electron microscopy (cryo-TEM) and small angle X-ray scattering (SAXS). In vitro cytotoxicity of BAI liposomes against HeLa cells was evaluated by MTF assay. BAI loaded FR-targeted liposomes showed higher cytotoxicity and cellular uptake compared with non-targeted liposomes. The results suggested that L-FA-BAI could enhance anti-tumor efficiency and should be an effective FR-targeted carrier system for BAI delivery. (C) 2015 Elsevier B.V. All rights reserved.