文献类型：期刊文献

英文题名：Photopharmacology beyond azobenzene photoswitches

作者：Guo, Huichao;Dai, Jinghong;Deng, Long;Zhang, Zhiwei[1];Tian, He;Zhang, Junji[1]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Inst Fine Chem,Key Lab Adv Mat,Sch Chem & Mol Engn, Shanghai, Peoples R China; East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Inst Fine Chem,Sch Chem & Mol Engn, Shanghai, Peoples R China

年份：2025

卷号：3

期号：4

外文期刊名：RESPONSIVE MATERIALS

收录：WOS:【ESCI(收录号:WOS:001602661300001)】；

基金：This work is supported by the National Natural Science Foundation of China (22378121, 22478118). J.Z. acknowledges the Shanghai Natural Science Foundation Project (23ZR1479500, 23JC1401700). Z.Z. acknowledges the Young Elite Scientists Sponsorship Program (2023) by the Chinese Chemical Society (CCS).

语种：英文

外文关键词：photopharmacology; photoswitchable drugs; photoswitches; precision medicine

摘要：Photopharmacology harnesses photoswitchable molecules to reversibly and precisely modulate biological activities, offering exceptional spatial and temporal control through non-invasive illumination. Traditionally, azobenzene-based photoswitches have dominated this field due to their robust photochemistry and synthetic simplicity. Recent advances, however, have introduced diverse alternatives featuring novel photoresponsive cores beyond the classical azo (-N=N-) moiety. These novel molecular scaffolds exhibit gratifying features, including exceptional thermal bistability, near-quantitative photoconversion efficiencies, and long-wavelength photoactivation, significantly improving their suitability for biological applications. This review systematically highlights recent progress in photopharmacology beyond azobenzenes, critically discusses their pros and cons, and provides valuable insights for the rational selection of photoswitches tailored to specific therapeutic contexts, ultimately aiming to broaden their biomedical applicability and facilitate advanced precision medicine.