文献类型：期刊文献

英文题名：Ligand-controlled switch in diastereoselectivities: catalytic asymmetric construction of spirocyclic pyrrolidine-azetidine/oxe(thie)tane derivatives

作者：Deng, Hua[1,2];Jia, Renmeng[1,2];Yang, Wu-Lin[1,2];Yu, Xingxin[1,2];Deng, Wei-Ping[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2019

卷号：55

期号：51

起止页码：7346

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000472221100010)，CCR-EXPANDED(收录号:WOS:000472221100010)】；

基金：This work was supported by the National Natural Science Foundation of China (no. 21772038) and the Fundamental Research Funds for the Central Universities.

语种：英文

摘要：An efficient catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides with four-membered ring-containing exocyclic alkenes has been developed, and either the exo or endo spirocyclic pyrrolidine-azetidine/oxe(thie)tane derivatives were diastereodivergently generated by employing Cu(i)/tBu-Phosferrox and a Cu(i)/N,O-ligand complex, respectively. Notably, various heteroatom-containing (N, O, S) exocyclic alkenes were found to be well-tolerated in this transformation.